Tetrahedron

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

F Cottet, M Schlosser

Index: Cottet, Fabrice; Schlosser, Manfred Tetrahedron, 2004 , vol. 60, # 51 p. 11869 - 11874

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Citation Number: 19

Abstract

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2- chloro-4-(trifluoromethyl) pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4-(trifluoromethyl) pyridine-3-carboxylic acid () from this precursor and the other 6-chloro-4-(trifluoromethyl) pyridine-2-and-3-carboxylic acids (and) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl) pyridine. In the ...