Synlett

Copper (II) triflate as a double catalyst for the one-pot click synthesis of 1, 4-disubstituted 1, 2, 3-triazoles from benzylic acetates

S Fukuzawa, E Shimizu, S Kikuchi

Index: Fukuzawa, Shin-Ichi; Shimizu, Eiji; Kikuchi, Satoshi Synlett, 2007 , # 15 p. 2436 - 2438

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Citation Number: 13

Abstract

Abstract Copper (II) triflate doubly catalyzed the substitution of benzylic acetates by TMSN 3 and the subsequent 1, 3-dipolar addition with an alkyne in one pot. This procedure afforded the preparation of 1, 4-disubstituted 1, 2, 3-triazoles in good yields starting from the easily accessible acetates without isolating an organic azide using a single catalyst.