Synthesis and biological evaluation of [18F] bicalutamide, 4-[76Br] bromobicalutamide, and 4-[76Br] bromo-thiobicalutamide as non-steroidal androgens for prostate …

EE Parent, CS Dence, C Jenks, TL Sharp…

Index: Adams, David J.; Clark, James H.; Nightingale, David J. Synthetic Communications, 1998 , vol. 28, # 23 p. 4295 - 4301

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Citation Number: 30

Abstract

... J. Med. ... in the tracer-level radiochemical synthesis of 4-[ 18 F]bicalutamide using this convergent synthesis, we modified our synthetic route to ... 23, it was necessary to reduce sulfoxide 25 under the conditions consistent with work on the tracer level (ie, normal atmosphere, H 2 O ...