Nickel??Catalyzed Heck??Type Alkenylation of Secondary and Tertiary α??Carbonyl Alkyl Bromides

…, D Liu, J Yuan, L Zheng, L Meng, A Lei

Index: Liu, Chao; Tang, Shan; Liu, Dong; Yuan, Jiwen; Zheng, Liwei; Meng, Lingkui; Lei, Aiwen Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3638 - 3641

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Citation Number: 72

Abstract

Since its development in the early 1970s, the palladiumcatalyzed Heck reaction has become a powerful tool for the alkenylation of aryl and alkenyl electrophiles in chemical synthesis [Eq.(1)].[1] Thus far, alkyl halides have had limited application in Heck-type reactions, with only isolated examples available for primary alkyl halides [1b, 2] and both secondary and tertiary alkyl halides remaining almost unstudied.[3] This may be because of facile β- ...