A different approach to enantioselective organic synthesis: absolute asymmetric synthesis of organometallic reagents

A Lennartson, S Olsson, J Sundberg…

Index: Lennartson, Anders; Olsson, Susanne; Sundberg, Jonas; Hakansson, Mikael Angewandte Chemie, International Edition, 2009 , vol. 48, # 17 p. 3137 - 3140

Full Text: HTML

Citation Number: 42

Abstract

Abstract Voilà, optical activity: Both enantiomers of 1-chloroindene have been synthesized in high selectivity from solely achiral starting materials, and without using optically active catalysts (see scheme). These symmetry-breaking syntheses provide a proof-of-concept for a new approach to asymmetric synthesis. NCS= N-chlorosuccinimide.