Chemical Communications

Quinuclidine N-oxide: a potential replacement for HMPA

IA O'Neil, D Wynn, JYQ Lai

Index: O'Neil, Ian A.; Lai, Justine Y. Q.; Wynn, Duncan Chemical Communications, 1999 , # 1 p. 59 - 60

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Citation Number: 12

Abstract

There are numerous significant and important reactions in organic synthesis which require the addition of hexamethylphosphoric triamide (HMPA) to render them viable. 1 HMPA is a dipolar aprotic compound with a superb ability to form cation–ligand complexes and it can enhance the rates of a wide variety of main group organometallic reactions. In addition, it can also influence the regio-and stereo-chemistry of key reactions such as enolate ...