Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives

MH Norman, L Liu, M Lee, N Xi, I Fellows…

Index: Menezes, Royce; Smith, Michael B. Synthetic Communications, 1988 , vol. 18, # 4 p. 1625 - 1636

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Citation Number: 40

Abstract

... Volume: Page ... For the preparation of the isomeric pyrrolidinone derivative 21, tert-butyl 2-oxopyrrolidine-1-carboxylate, 18, was first alkylated with benzyl bromide(14 ... a Reagents: (a) LDA, THF, −78 °C → 0 °C, BnBr; (b) TFA, DCM 0 °C, NaOH, rt; (c) 4-nitrophenyl ...

Homolytic aziridine opening (aza variant of cyclopropylcarbinyl-homoallyl rearrangement) by addition of tributyltin radical to N-acylaziridines. Factors contributing to …

[Werry, Juergen; Stamm, Helmut; Lin, Pen-Yuan; Falkenstein, Reinhard; Gries, Stefan; Irngartinger, Hermann Tetrahedron, 1989 , vol. 45, # 16 p. 5015 - 5028]

Intramolecular radical trapping in “set” ring opening of N-enoyl aziridines. A new mechanistic probe and a new synthesis of pyrrolidones.

[Bentz, G.; Besbes, N.; Laurent, A.; Stamm, H. Tetrahedron Letters, 1987 , vol. 28, # 22 p. 2511 - 2512]

Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives

[Norman, Mark H.; Liu, Longbin; Lee, Matthew; Xi, Ning; Fellows, Ingrid; D'Angelo, Noel D.; Dominguez, Celia; Rex, Karen; Bellon, Steven F.; Kim, Tae-Seong; Dussault, Isabelle Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1858 - 1867]