Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analog N-oxaloglycine and its derivatives

CJ Cunliffe, TJ Franklin, NJ Hales…

Index: Cunliffe; Franklin; Hales; Hill Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2652 - 2658

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Citation Number: 118

Abstract

Background. Inhibition of prolyl hydroxylase (EC 1.14. 11.2)[procollagen-L-proline, 2- oxog1utarate: oxygen oxidoreductase (4-hydroxylating) 12 is of therapeutic interest because the enzyme is necessarily involved3 in the biosynthesis of the collagen deposited during life- threatening fibroses. During these fibrotic states the involved organ or tissue becomes unbearably congested with inappropriately large amounts of collagen. Chronic liver ...