Tetrahedron

Development of an organo-and enzyme-catalysed one-pot, sequential three-component reaction

A Kinnell, T Harman, M Bingham, A Berry, A Nelson

Index: Kinnell, Angela; Harman, Thomas; Bingham, Matilda; Berry, Alan; Nelson, Adam Tetrahedron, 2012 , vol. 68, # 37 p. 7719 - 7722

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Citation Number: 9

Abstract

A one-pot, three-component process is described which involves both organo-and enzyme- catalysed carbon–carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilution with additional aqueous buffer, and addition of pyruvate and an aldolase enzyme variant, a second aldol reaction occurs to yield a final product. Crucially, it was possible to develop a reaction in ...