Trichloromethyl chloroformate. Reaction with amines, amino acids, and amino alcohols

K Kurita, T Matsumura, Y Iwakura

Index: Kurita,K. et al. Journal of Organic Chemistry, 1976 , vol. 41, p. 2070 - 2071

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Citation Number: 66

Abstract

The reactions of TCF with aniline were carried out under conditions similar to those employed in the phosgene method. As expected, phenyl isocyanate was obtained in high yields (78-89%) either from the hydrochloride or the free base. It was also confirmed that 0.5 mol of TCF was sufficient to convert 1 mol of the amine to the isocyanate. Treatment of p- phenylenediamine hydrochloride with TCF in dioxane, on the other hand, gave only poor ...