Tetrahedron

Synthesis of organophosphorus compounds via silyl esters of phosphorous acids

K Afarinkia, CW Rees, JIG Cadogan

Index: Afarinkia, Kamyar; Rees, Charles W.; Cadogan, John I. G. Tetrahedron, 1990 , vol. 46, # 20 p. 7175 - 7196

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Citation Number: 99

Abstract

The addition of trimethylsilyloxy phosphorus (III) derivatives generated in situ to imines at room temperature provides a mild selective and high yielding route to α- aminoalkylphosphorate and α-aminoalkylphenylphosphinate esters. Isocyanates and carbodiimides react similarly to give phosphonoureas and phosphonoguarnidines respectively aldehydes and ketones are much less reactive and cyanides are inert.