Synthesis and sugar reducing activity of dioxamoyl derivatives of sulfanilamide

…, VP Chernykh, PA Petyunin, AV Chuvurin…

Index: Bannyi, I. P.; Chernykh, V. P.; Petyunin, P. A.; Chuvurin, A. V.; Chaleeva, L. D.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 1 p. 33 - 37 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 1 p. 43 - 47

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Abstract

Esters II and amides III were obtained by methods described in [6]. In the reaction of amides III with monoethyl oxalate monoacid chloride (ethoxalyl chloride), NR-amides of 4- (ethoxalylamino) benzenesulfonyloxamic acid (IV, Table i) are formed in yields of 72-86%. The latter with primary alkylamines form NR-amides of 4-(N-R'-oxamido) benzenesulfonyloxamic acid (V, Table 2) in yields of 67-90%. Compounds IV and V are ...