Tetrahedron

Synthesis of sphinganine analogues modified in the head group

T Kolter, G van Echten-Deckert, K Sandhoff

Index: Kolter, Thomas; Van Echten-Deckert, Gerhild; Sandhoff, Konrad Tetrahedron, 1994 , vol. 50, # 47 p. 13425 - 13432

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Citation Number: 20

Abstract

The synthesis of sphinganine analogues modified in the head group is reported. The target compounds are efficiently prepared by means of the Henry reaction. Synthesis and results of preliminary investigations of the derivatives as potential inhibitors of sphingolipid biosynthesis are presented.