Synlett

Nafion-H: An efficient and recyclable heterogeneous catalyst for the one-pot synthesis of 2, 3-disubstituted 4-(3H)-quinazolinones under solvent-free microwave …

BV Lingaiah, G Ezikiel, T Yakaiah, GV Reddy, PS Rao

Index: Lingaiah, B. Venkat; Ezikiel; Yakaiah; Reddy, G. Venkat; Shanthan Rao Synlett, 2006 , # 15 p. 2507 - 2509

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Citation Number: 27

Abstract

Abstract A one-pot synthesis of 2, 3-disubstituted 4-(3H)-quinazolinones has been carried out efficiently by the three-component coupling of isatoic anhydride/anthranilic acid, orthoesters, and amines in the presence of Nafion-H (a perfluorinated resin-supported sulfonic acid) as a heterogeneous catalyst. The reaction occurred within a few minutes under solvent-free microwave irradiation conditions to afford the products in good yields. ...

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