Tetrahedron letters

Synthesis of carbamoylpyridine and imidazo [1, 5-a] pyridin-1, 3-diones via ortho-acetalhydantoin intermediates

…, E Moreau, N Desbois, Y Blache, O Chavignon…

Index: Chezal, Jean M.; Moreau, Emmanuel; Desbois, Nicolas; Blache, Yves; Chavignon, Olivier; Teulade, Jean C. Tetrahedron Letters, 2004 , vol. 45, # 3 p. 553 - 556

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Citation Number: 8

Abstract

Several 5-substituted hydantoins display a wide range of biological properties, 1 and have proved to be useful precursors of α-amino acids after alkaline hydrolytic degradation 2 or enzymatic reactions. 3 Different approaches have been used for the construction of pyridine (or diazepine) moieties. 5-Substituted hydantoins have been found to be valuable precursors of a great variety of heterocyclic systems: 5-methoxy-3-phenylhydantoin reacts with various ...