Chemical Communications

Enzymatic synthesis of β-mannosyl phosphates on solid support

I Sprung, A Ziegler, SL Flitsch

Index: Sprung, Ines; Ziegler, Alexandra; Flitsch, Sabine L. Chemical Communications, 2002 , # 22 p. 2676 - 2677

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Citation Number: 2

Abstract

Dolichol phosphate 1 is a member of a class of polyisoprenoid phosphates that are linked to intermediates of glycoconjugate biosynthesis, notably that of N-glycans and bacterial cell surface polysaccharides. 1 Consequently, many of the glycosyltransferases involved in these biosynthetic processes require conjugation of substrate to polyisoprenoids for recognition. An example of such a class of glycosyltransferase is the Dol-P-Man synthase, which catalyses the ...