Synthesis and microbiological evaluation of novel [N-acetyl-2, 6-diarylpiperidin-4-yl]-5-spiro-4-acetyl-2-(acetylamino)-Δ 2-1, 3, 4-thiadiazolines

S Balasubramanian, C Ramalingan, G Aridoss…

Index: Balasubramanian; Ramalingan; Aridoss; Parthiban; Kabilan Medicinal Chemistry Research, 2004 , vol. 13, # 5 p. 297 - 311

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Citation Number: 22

Abstract

Abstract. Some novel spiropiperidinyl thiadiazolines have been synthesized and their bacterial activity against Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Klepsiella pneumoniae and antifungal activity against Cryptococcus neoformans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus were evaluated. Compound 23 exhibited potent antibacterial activity in vitro against ...