Direct synthesis of thioethers from sulfonyl chlorides and activated alcohols

MT Martin, AM Thomas, DG York

Index: Martin, Michael T; Thomas, Alford M; York, Douglas G Tetrahedron Letters, 2002 , vol. 43, # 12 p. 2145 - 2147

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Citation Number: 22

Abstract

Formation of thioethers is an important synthetic process typically carried out by coupling the corresponding thiols with an activated derivative of the alcohol in the presence of base, or alternatively by a Lewis acid-catalyzed reaction with activated alcohols. 1., 2., 3. and 4. Recent reports have shown that these thiols can be obtained in good yields and purity via a zinc–dichlorodimethylsilane–dimethylacetamide-mediated reduction of aryl sulfonyl ...