Tetrahedron

Design, synthesis, and characterization of a novel hexa-azacyclophane and interactions with d (CGCA 3 T 3 GCG) 2, ctDNA and T4DNA

…, FC Lightstone, KA Browne, ME Petyak, J Luo

Index: Bruice, Thomas C.; Yip, Yu Chi; Blasko, Andrei; Lightstone, Felice C.; Browne, Kenneth A.; Petyak, Mark E.; Luo, Jia Tetrahedron, 1997 , vol. 53, # 24 p. 8105 - 8120

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Abstract

A novel polyazacyclophane hexa-amine (1) has been designed, synthesized and characterized by X-ray crystallography, 1H NMR and fluorescence spectroscopy. 1 has the structural shape and disposition of charges complementary to the major groove of B-DNA. Acid dissociation constants for the protonated 1 were pKa1 (D)= 4.8 and pKa2 (D)= 8.5. Equilibrium constants for the binding of 1 to ctDNA and T4 DNA were 1.2× 105 and 1.8× ...