Synthesis of 4, 4′-biquinazoline alcohols as chiral catalysts in enantioselective alkynylation of aldehydes with phenyl acetylene

M Catir, M Cakici, S Karabuga, S Ulukanli, E Şahin…

Index: Catir, Mustafa; Cakici, Murat; Karabuga, Semistan; Ulukanli, Sabri; Sahin, Ertan; Kilic, Hamdullah Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2845 - 2853

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Citation Number: 13

Abstract

Optically active propargylic alcohols are important chiral-building blocks in asymmetric synthesis, while the asymmetric addition of a terminal alkyne to an aldehyde is one of the most important procedures to prepare these chiral-building blocks. In this work, a family of chiral 4, 4′-biquinazoline alcohols has been conveniently prepared from the easily accessible (S)-2-acetoxycarboxylic acid chlorides by reaction sequences beginning with ...