Conformational effects on the activity of drugs. 4. Cyclic analogs of 1-(p-nitrophenyl)-2-isopropylaminoethanol. Synthesis and evaluation of the adrenergic. beta.- …

A Balsamo, B Macchia, F Macchia…

Index: Balsamo,A. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 224 - 227

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Citation Number: 7

Abstract

The structure of 9 was assigned on the basis of the fact that the addition of nucleophiles under acidic conditions to 2-aryl-substituted aziridines takes place preferentially at the benzylic carbon. I7 The nmr spectrum of 9 did not provide unequivocal evidence to determine the position of the methoxy group, because the conversion of the basic nitrogen of 9 to the positively charged atom resulted in a downfield shift'* not only of the methylenic ...