Tetrahedron: Asymmetry

Palladium-catalyzed asymmetric allylic alkylation using (R)-2-(methoxymethyl) pyrrolidine-derived aminophosphine ligands

T Mino, Y Tanaka, M Sakamoto, T Fujita

Index: Mino, Takashi; Tanaka, Youichi; Sakamoto, Masami; Fujita, Tsutomu Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2435 - 2440

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Citation Number: 34

Abstract

Palladium-catalyzed asymmetric allylic alkylation of 1, 3-diphenyl-2-propenyl acetate 7a using a dimethyl malonate–BSA–LiOAc system has been successfully carried out in the presence of new chiral aminophosphine ligands such as 4 in good yields with good enantioselectivities (up to 96% ee).