Synthesis and Testing of Beta??Cell??Specific Streptozotocin??Derived Near??Infrared Imaging Probes

C Ran, P Pantazopoulos, Z Medarova…

Index: Ran, Chongzhao; Pantazopoulos, Pamela; Medarova, Zdravka; Moore, Anna Angewandte Chemie - International Edition, 2007 , vol. 46, # 47 p. 8998 - 9001

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Citation Number: 19

Abstract

Pancreatic beta-cells are responsible for the production and release of insulin, a hormone that controls the level of glucose in the blood. Beta-cell mass is markedly reduced in both insulin-dependent and non-insulin-dependent diabetes mellitus.[1–5] The noninvasive estimation of beta-cell mass by imaging would have a significant impact on the management of clinical diabetes, pancreas-and/or isletcell transplantation, and the understanding of the ...