European Journal of Organic Chemistry

Asymmetric total syntheses of cochliomycin A and zeaenol

N Jana, S Nanda

Index: Jana, Nandan; Nanda, Samik European Journal of Organic Chemistry, 2012 , # 23 p. 4313 - 4320

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Citation Number: 11

Abstract

Abstract The first asymmetric total syntheses of two resorcylic acid lactones (RALs)– cochliomycin A and zeaenol–have been achieved in a divergent way. The main highlight of our strategy involves successful application of stereoselecive Keck allylation and Julia– Kocienski olefination to access an advanced intermediate, by starting from L-tartaric acid as a chiral pool compound. This intermediate is coupled with a trisubstituted benzoic acid to ...

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