Iodotrimethylsilane??Accelerated One??Pot Synthesis of 5??Unsubstituted 3, 4??Dihydropyrimidin??2 (1H)??ones: A Novel Procedure for the Biginelli??Like …

G Sabitha, KB Reddy, R Srinivas…

Index: Sabitha, Gowravaram; Reddy, Kusuma B.; Srinivas, Rangavajjula; Yadav, Jillu S. Helvetica Chimica Acta, 2005 , vol. 88, # 11 p. 2996 - 2999

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Citation Number: 25

Abstract

Abstract A novel Biginelli-like cyclocondensation reaction is efficiently catalyzed by iodotrimethylsilane (Me 3 SiI) in MeCN. The reaction proceeds at room temperature by a three-component one-pot condensation of ketones with aldehydes and urea to afford 5- unsubstituted 3, 4-dihydropyrimidin-2 (1H)-ones in good yields (Scheme 1 and Table).

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