Bicyclic brominated furanones: a new class of quorum sensing modulators that inhibit bacterial biofilm formation

…, OA Abdel-Razek, F Cheng, D Bandyopadhyay…

Index: Yang, Sijie; Abdel-Razek, Osama A.; Cheng, Fei; Bandyopadhyay, Debjyoti; Shetye, Gauri S.; Wang, Guirong; Luk, Yan-Yeung Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1313 - 1317

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Citation Number: 5

Abstract

Abstract Both natural and synthetic brominated furanones are known to inhibit biofilm formation by bacteria, but their toxicity to mammalian cells is often not reported. Here, we designed and synthesized a new class of brominated furanones (BBFs) that contained a bicyclic structure having one bromide group with well-defined regiochemistry. This class of molecules exhibited reduction in the toxicity to mammalian cells (human neuroblastoma ...