Il Farmaco

Synthesis, binding affinity and selectivity of new β 1-and β 2-adrenoceptor blockers

V Brizzi, M Francioli, M Brufani, L Filocamo, G Bruni…

Index: Brizzi, Vittorio; Francioli, Marco; Brufani, Mario; Filocamo, Luigi; Bruni, Giancarlo; Massarelli, Paola Farmaco, 1999 , vol. 54, # 11-12 p. 713 - 720

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Citation Number: 8

Abstract

The synthesis of a new series of sesamol derivatives with β-adrenergic blocking activity is described. The affinity and selectivity of these compounds for β1-and β2-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the β2-receptors of rat lung membranes and two of them provide interesting selectivity.