Cyclization of ortho-halogenated N-acylbenzylamines: A formal synthesis of (±)-cherylline

SV Kessar, P Singh, R Chawla, P Kumar

Index: Kessar, Satinder V.; Singh, Paramjit; Chawla, Ravinder; Kumar, Pawan Journal of the Chemical Society, Chemical Communications, 1981 , # 20 p. 1074 - 1075

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Citation Number: 16

Abstract

ortho-Halogenated N-alkyl-N-acylbenzylamines can be cyclised to dihydroisoquinolones by reaction with KNH2 in liquid NH3 or lithium di-isopropylamide in tetrahydrofuran under photolytic and thermal conditions; the procedure has been employed to synthesize (±)- cherylline.

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