Tetrahedron letters

A new route towards N-(α-methoxybenzyl) aziridines

M D'hooghe, A Hofkens, N De Kimpe

Index: D'hooghe, Matthias; Hofkens, Arn; De Kimpe, Norbert Tetrahedron Letters, 2003 , vol. 44, # 6 p. 1137 - 1139

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Citation Number: 8

Abstract

A new synthesis of N-(α-methoxyarylmethyl)-2, 2-dimethylaziridines is presented. Different benzaldehydes were converted into the corresponding imines upon reaction with 2-bromo-2- methylpropylamine. Treatment of the latter imines with sodium methoxide afforded N-(α- methoxyarylmethyl)-2, 2-dimethylaziridines in good yields.