Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives

G Nam, TW Kang, JH Shin, KI Choi

Index: Nam, Ghilsoo; Kang, Tae Won; Shin, Jung Hyu; Choi, Kyung Il Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 569 - 572

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Citation Number: 21

Abstract

The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.