Synthesis of hyperbranched glycodendrimers incorporating α-thiosialosides based on a gallic acid core

SJ Meunier, Q Wu, SN Wang…

Index: Meunier, Serge J.; Wu, Quigquan; Wang, Sho-Nong; Roy, Rene Canadian Journal of Chemistry, 1997 , vol. 75, # 11 p. 1472 - 1482

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Citation Number: 49

Abstract

Hyperbranched glycodendrimers containing sialic acid residues were synthesized in order to further understand the multivalency effect and its role in carbohydrate-protein interactions. Gallic acid 7 as trivalent core and oligoethylene glycol derivatives as hydrophilic spacers were used to scaffold the dendritic backbones. α-Thiosialoside 16 was conjugated onto N- chloroacetylated dendritic precursors 13, 14, and 26 by nucleophilic substitution to afford ...