. beta. 1-Selective adrenoceptor antagonists. 3. 4-Azolyl linked phenoxypropanolamines

…, LC Blaber, DT Burden, RA Melarange

Index: Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509

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Citation Number: 22

Abstract

A series of 4-substituted phenoxypropanolamines has been prepared and examined for P- adrenoceptor activity. The 4-substituenta, di-and triazole ring systems connected to the phenoxy ring by different length chains, were chosen as a means of introducing cardioselectivity. This has been achieved, especially in the l-[4-[(4-chloropyrazol-lyl) methoxy] phenoxy]-3-(isopropylamino)-2-propanol (ll), the 4-[(2H-1, 2, 3-triazol-2-yl) ...