Saccharin sulfonic acid catalyzed N-Boc protection of amines and formation of tert-butyl ethers from alcohols
F Shirini, MA Zolfigol, M Abedini
Index: Shirini; Zolfigol; AbediniM. Journal of the Iranian Chemical Society, 2010 , vol. 7, # 3 p. 603 - 607
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Citation Number: 23
Abstract
Abstract Saccharin sulfonic acid (SaSA), as a stable reagent is easily prepared by the reaction of saccharin with neat chlorosulfonic acid at room temperature. This compound is able to catalyze conversion of amines to their corresponding N-Boc protected amines with (Boc) 2 O. Alcohols were also converted to their corresponding tert-butyl ethers. All reactions took place under mild conditions giving the desired products in good to high yields.
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