Studies on 6-aminoquinolones: Synthesis and antibacterial evaluation of 6-amino-8-ethyl-and 6-amino-8-methoxyquinolones

V Cecchetti, O Tabarrini, S Sabatini, H Miao…

Index: Cecchetti, Violetta; Tabarrini, Oriana; Sabatini, Stefano; Miao, Hua; Filipponi, Enrica; Fravolini, Arnaldo Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2465 - 2471

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Citation Number: 20

Abstract

From our quantitative structure–activity relationship (QSAR) study on a large set of 6- aminoquinolones, which indicated that a group larger than methyl could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characterized by the presence of an ethyl or a methoxy group at C-8 position. The antibacterial evaluation shows that, while the 8-ethyl derivatives were devoid of any antibacterial activity, the introduction ...