Journal of Medicinal Chemistry

Some amino and ammonio nitrogen mustard analogs

CC Price, G Kabas, I Nakata

Index: Price,C.C. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 650 - 655

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Citation Number: 13

Abstract

Biological data on these compounds were reported in detail The amino mustards were found to have a single LD5o of 3-8 mg./kg. compared to 3 mg./kg. for HS-2. In suppression of Ehrlich ascites tumor, IIa was the most active compound, being slightly superior to"-2. However, it is of interest to note that in the primary aiiiine series IIa is the most active and IVa is the least active while in the less active tertiary amine series, the order is reversed. This ...