Total synthesis and biological evaluation of (−) apicularen A and analogues thereof
…, DW Kim, R Baati, P Giannakakou
Index: Nicolaou; Kim, David W.; Baati, Rachid; O'Brate, Aurora; Giannakakou, Paraskevi Chemistry - A European Journal, 2003 , vol. 9, # 24 p. 6177 - 6191
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Citation Number: 64
Abstract
Abstract Apicularen A (1) and related benzolactone acylenamines belong to a growing class of novel natural products possessing highly cytotoxic properties. The challenging structure of 1 includes a 10-membered macrolactone ring, a tetrahydropyran system, an o, m-substituted phenol and a doubly unsaturated acyl group attached on the side chain enamine functionality. The total synthesis of apicularen A described herein involves a strategy ...
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