A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1, 3-dioxane-thromboxane receptor antagonists and- …

N Ackerley, AG Brewster, GR Brown…

Index: Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628

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Citation Number: 38

Abstract

A Novel Approach to Dual-Acting Thromboxane Receptor AntagonistJSynthase Inhibitors Based on the Link of 1,3-Dioxane-Thromboxane Receptor Antagonists and -Thromboxane Synthase Inhibitors ... Norman Ackerley, Andrew G. Brewster, George R. Brown,* David S. Clarke, Alan J. Foubister, Stephen J. Griffin, Julian A. Hudson, Michael J. Smithers, and Paul R. 0. Whittamore Cardiovascular and Metabolism Department, ZENECA Pharmaceuticals, Alderley Park, ...