Binding of β-Carbolines at 5-HT 2 serotonin receptors

B Grella, M Teitler, C Smith, K Herrick-Davis…

Index: Grella, Brian; Teitler, Milt; Smith, Carol; Herrick-Davis, Katharine; Glennon Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4421 - 4425

Full Text: HTML

Citation Number: 39

Abstract

A series of ring-substituted (ie, methoxy and bromo) 3, 4-dihydro-and 1, 2, 3, 4-tetrahydro-β- carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy-substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected β-carbolines.