A convenient one-pot synthesis of trisubstituted 1, 3, 5-triazines through intermediary amidinothioureas

…, AB Baraiya, AN Pandya, HB Jalani, V Sudarsanam…

Index: Kaila, Jitendra C.; Baraiya, Arshi B.; Pandya, Amit N.; Jalani, Hitesh B.; Sudarsanam; Vasu, Kamala K. Tetrahedron Letters, 2010 , vol. 51, # 11 p. 1486 - 1489

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Citation Number: 15

Abstract

A thiophile-promoted one-pot synthesis of trisubstituted 1, 3, 5-triazines starting from isothiocyanates, N, N-diethylamidines, and carbamidines has been studied. The reaction proceeds through the formation of intermediary amidinothioureas, which react with carbamidines in the presence of mercury (II) chloride to generate the desired 1, 3, 5-triazines in good to moderate yields (40–70%).