Efficient synthesis of primary 2-aminothiols from 2-aminoalcohols and methyldithioacetate

G Mercey, D Brégeon, AC Gaumont, J Levillain…

Index: Mercey, Guillaume; Bregeon, Delphine; Gaumont, Annie-Claude; Levillain, Jocelyne; Gulea, Mihaela Tetrahedron Letters, 2008 , vol. 49, # 46 p. 6553 - 6555

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Citation Number: 11

Abstract

Most of the methods reported for the preparation of 2-aminothiols start from 2-aminoalcohols. The main drawback of these methods is probably that a multi-step sequence is generally required, including addition of a sulfur nucleophile and protection/deprotection of amino and thiol groups. 6 A few other methods are limited by less accessible starting materials such as thiiranes, 7 aziridines, 8 or 2-thiazolidinones. 9 Thus, developing a convenient ...