Trace amine-associated receptor 1 (TAAR 1) is activated by amiodarone metabolites

AN Snead, M Miyakawa, ES Tan, TS Scanlan

Index: Snead, Aaron N.; Miyakawa, Motonori; Tan, Edwin S.; Scanlan, Thomas S. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5920 - 5922

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Citation Number: 12

Abstract

Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines. Several of these amiodarone derivatives act as specific agonists of the G protein-coupled receptor ( ...