Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance

…, TC Hancox, I Dale, W Dangerfield, P Charlton…

Index: Wang, Shouming; Ryder, Hamish; Pretswell, Ian; Depledge, Paul; Milton, John; Hancox, Timothy C.; Dale, Ian; Dangerfield, Wendy; Charlton, Peter; Faint, Richard; Dodd, Rory; Hassan, Stephanie Bioorganic & Medicinal Chemistry Letters, 2002 , vol. 12, # 4 p. 571 - 574

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Citation Number: 29

Abstract

... Thus, when anthranilic acids (5) were reacted with acid chlorides (10) in pyridine at 0 °C, benzooxazinones (6) were obtained as crystalline products. The subsequent reflux with amines (11) and catalytic amount of pTSA in toluene gave a mixture of quinazolinones (7) and uncyclized diamides (8), which were converted to products (7) by heating in acetic acid and concentrated sulfuric acid (9:1) at 100 °C for 15 min. ...