Potential antitumor agents. 35. Quantitative relationships between antitumor (L1210) potency and DNA binding for 4'-(9-acridinylamino) methanesulfon-m-anisidide (m …

BC Baguley, WA Denny, GJ Atwell…

Index: Baguley; Denny; Atwell; Cain Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 520 - 525

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Citation Number: 90

Abstract

Method F. From Compound 22. To a solution of 22 (550 mg, 1.76" 01) in methanol (17 mL) was added 6 N aqueous HCI (1.7 mL), and the solution was stirred for 6 h at 40" C. The reaction solution was evaporated in vacuo and then dried under high vacuum to give a viscous brown oil (540 mg). Purification of the oil with preparative TLC (silica; ethyl acetate- methanol, 201) provided colorless crystals of 15. The product was identical with 15 ...