Monomethylthio analogs of 1-(2, 4, 5-trimethoxyphenyl)-2-aminopropane

P Jacob III, G Anderson III, CK Meshul…

Index: Jacob III; Anderson III; Meshul; Shulgin; Castagnoli Jr. Journal of Medicinal Chemistry, 1977 , vol. 20, # 10 p. 1235 - 1239

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Citation Number: 26

Abstract

Regiospecific syntheses of the three monomethylthio analogues of 1-(2, 4, 5- trimethoxypheny1)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are ...