Synthesis and effect of two new penetration enhancers on the transdermal delivery of 5-fluorouracil through excised rat skin.
RM Hanif, P Qineng, M Fenzhu
Index: Hanif, Raja Muhammad; Qineng, Ping; Fenzhu, Muo Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 9 p. 1428 - 1431
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Citation Number: 6
Abstract
The tetrahydrogeraniol (THG) derivative, ethyl-(3, 7-dimethyl octyl thio) acetate (EDOTA) was prepared by reacting tetrahydrogeranyl bromide (obtained by reaction of 40% hydrobromic acid and concentrated sulfuric acid) with ethyl 2-mercaptoacetate, while 3, 7- dimethyl octyl propionate (DOP) was synthesized by a common esterification reaction by reacting THG with propionic acid in the presence of cyclohexane and concentrated ...
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