New benzo [h][1, 6] naphthyridine and azepino [3, 2-c] quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological …

…, R Bureau, B Pfeiffer, P Renard, S Rault

Index: Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080

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Citation Number: 46

Abstract

A series of benzo [h][1, 6] naphthyridine and azepino [3, 2-c] quinoline derivatives were prepared and evaluated to determine the necessary requirements for high affinity on the 5- HT4 receptors and high selectivity versus other receptors. The compounds were synthesized by substituting the chlorine atom of benzonaphthyridines and azepinoquinolines with various N-alkyl-4-piperidinylmethanolates. They were evaluated in binding assays with [ ...