Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted) quinolones

…, M Takamatsu, Y Inoue, Y Kawahata…

Index: Uno, Toshio; Takamatsu, Masanori; Inoue, Yoshimasa; Kawahata, Yoshihiro; Iuchi, Koji; Tsukamoto, Goro Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2163 - 2169

Full Text: HTML

Citation Number: 27

Abstract

On the other hand, norfloxacin (NFLX, 2) 4 containing a fluorine atom and a piperazinyl group at the 6-and 7-position of quinolone, respectively, and its 8-fluor0 derivative (3) 5apb were found to show excellent antibacterial activities and a broad antibacterial spectrum. But the former has been reported to show low blood concentrations and low urinary recoveries after oral administration to animals, B and the latter was confiied to show significantly