Regioselective and enantioselective hydroformylation of dialkylacrylamides

GM Noonan, D Newton, CJ Cobley…

Index: Noonan, Gary M.; Newton, David; Cobley, Christopher J.; Suarez, Andres; Pizzano, Antonio; Clarke, Matthew L. Advanced Synthesis and Catalysis, 2010 , vol. 352, # 6 p. 1047 - 1054

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Citation Number: 22

Abstract

Abstract Dimethylacrylamide can be hydroformylated with very high chemo-and regioselectivity. Asymmetric hydroformylation of this substrate is possible, provided steps are taken to minimise racemisation of the aldehyde products, and this work demonstrates the effect of various conditions and variables on racemisation. Using the Landis diazaphospholane ligands up to 68% ee can be realised under very mild conditions. ...