Tetrahedron

Synthesis of coumarin–nucleoside conjugates via Huisgen 1, 3-dipolar cycloaddition

I Kosiova, S Kovackova, P Kois

Index: Kosiova, Ivana; Kovackova, Sona; Kois, Pavol Tetrahedron, 2007 , vol. 63, # 2 p. 312 - 320

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Citation Number: 47

Abstract

An efficient synthesis of fluorescent coumarin–nucleoside conjugates via Cu (I) catalysed Huisgen 1, 3-dipolar cycloaddition is described. Starting from azidonucleosides and coumarin derivatives, products are obtained in good yields. The fluorescent properties of the newly prepared coumarin–nucleoside conjugates are determined.