Synthesis

An efficient entry to amino-substituted resorcylic acid derivatives for the synthesis of platensimycin and analogues

P Heretsch, A Giannis

Index: Heretsch, Philipp; Giannis, Athanassios Synthesis, 2007 , # 17 p. 2614 - 2616

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Citation Number: 24

Abstract

The aromatic subunit of platensimycin was synthesized by Nicolaou and co-workers in five steps from commercially available 2-nitroresorcinol (4) and its key features were directed ortho-metalation to attach the carboxylic acid moiety and microwave-assisted tert-butoxycarbonyl (Boc) deprotection (Scheme [2] ). ... Much to our surprise there are no other procedures reported in literature for the synthesis of such tetrasubstituted amino-resorcylic acids or their derivatives.